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UCI MIND Alzheimer’s Research

 2642 BIOLOGICAL SCIENCES III
 IRVINE , CA 92697
[P] (949) 824-3251
[F] (949) 824-0885
www.mind.uci.edu
https://gala.mind.uci.edu/
[email protected]
Linda Scheck
FOUNDED: --
INCORPORATED: 1967
 Printable 1 Page Summary
 Printable Profile
Organization DBA UCI MIND, UC Irvine Institute for Memory Impairments and Neurological Disorders, Alzheimer's Research, UC Irvine Alzheimer's Disease Research Center
Former Names Institute for Brain Aging and Dementia, IBAD (1995)
Organization received a competitive grant from the community foundation in the past five years No
Employer Identification Number 95-2540117 00005

Summary


Mission StatementMORE »

Researching ways to make memories last a lifetime

The mission of UCI MIND is to enhance the quality of life for older adults by researching genetic, clinical, and lifestyle factors that promote successful brain aging. Toward this end, UCI MIND engages in a variety of activities translating findings from the lab to improved clinical care.

Mission Statement

Researching ways to make memories last a lifetime

The mission of UCI MIND is to enhance the quality of life for older adults by researching genetic, clinical, and lifestyle factors that promote successful brain aging. Toward this end, UCI MIND engages in a variety of activities translating findings from the lab to improved clinical care.


FinancialsMORE »

Fiscal Year 2018
Projected Expenses $3,040,173.00
Projected Revenue $3,099,151.00

ProgramsMORE »

  • UCI MIND Alzheimer's Disease Research Center

Revenue vs. Expense ($000s)

Expense Breakdown 2016 (%)

Expense Breakdown 2015 (%)

Expense Breakdown 2014 (%)

For more details regarding the organization's financial information, select the financial tab and review available comments.


Overview


Mission Statement

Researching ways to make memories last a lifetime

The mission of UCI MIND is to enhance the quality of life for older adults by researching genetic, clinical, and lifestyle factors that promote successful brain aging. Toward this end, UCI MIND engages in a variety of activities translating findings from the lab to improved clinical care.


Background Statement

UCI MIND is home to the UCI Alzheimer’s Disease Research Center (ADRC), one of 30 centers of excellence across the country funded by the National Institute on Aging (NIA), a division of the National Institutes of Health (NIH).

As Orange County’s only federally-funded center, the UCI ADRC seeks to translate research findings into improved diagnosis, treatment, and care for people living with Mild Cognitive Impairment (MCI), Alzheimer’s disease, and related disorders, and to ultimately discover means to prevent and cure these conditions. Specifically, the UCI ADRC aims to:
  • Describe the cognitive and underlying brain changes that differentiate normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease.
  • Investigate ways to identify, diagnose, and treat Alzheimer’s disease and related disorders.
  • Better understand cognitive aging in special populations, including the oldest old and individuals with Down syndrome.
  • Engage older adults in a variety of studies on memory and aging and investigation of improved treatments.
  • Serve as the expert source of information on memory and aging for Orange County seniors, health care professionals, aging service providers, and the community at large.

To accomplish its aims, the UCI ADRC functions in six collaborative cores that include investigators from a variety of disciplines (e.g., neurology, neurobiology, nursing, geriatric medicine, social work, pathology, statistics):


Impact Statement


UCI MIND Institute Highlights


  • One of 30 designated Alzheimer’s Disease Research Centers (ADRC) funded by the National Institutes on Aging (NIA) and the only center in Orange County

  • One of 10 designated California Alzheimer’s Disease Centers (CADC) funded by the California Department of Public Health and the only center in Orange County

  • Established as an Organized Research Unit (ORU) in 1995 by founding director, Dr. Carl Cotman, Professor of Neurology and international leader in exercise and brain aging research

  • First and only Alzheimer’s disease mouse model to develop both plaques and tangles invented by Dr. Frank LaFerla, Co-Director of UCI MIND, Director of UCI ADRC, Dean of UCI Ayala School of Biological Sciences; model used by more than 150 researchers from over 20 countries worldwide

  • Predoctoral and postdoctoral training program to prepare the next generation of scientists and clinicians

  • First NIH-funded induced pluripotent stem (iPS) cell core in the ADRC network

  • Down Syndrome Program led by Dr. Ira T. Lott, Professor Emeritus, UC Irvine School of Medicine

  • The 90+ Study led by Dr. Claudia Kawas, Professor of Neurology and Neurobiology & Behavior

  • Longitudinal Study led by Dr. Aimee Pierce, Assistant Clinical Professor of Neurology and Medical Director of the UCI MIND Memory Assessment and Research Clinic

  • Member of National Clinical Trials Network and site for trials of promising therapies aiming to treat, prevent, and cure Alzheimer’s disease

  • The Consent-to-Contact (C2C) Registry, an online tool to match adults in Orange County with clinical research studies at UCI

  • Southern California Alzheimer’s Disease Research Conference attended by over 400 community members annually since 1989



Needs Statement

UCI MIND’s vision is based on the success of its world-renowned research faculty. Increased community engagement, expanded number of volunteer research participants and greater philanthropy from the community reflect successes. This foundation advances UCI MIND towards its five-year fundraising plan:

  • Raise $600,000 annually to expand clinical research to identify treatments that will prevent Alzheimer's disease.
  • Increase annual funding for educational outreach $50,000
  • Expand Consent to Contact, C2C, a registry of individuals interested in participating in studies/clinical trials as they are identified, $300,000
  • Endow research faculty professors to allow them to dedicate more time to research: $2M each
  • Initiate dialogue for a feasibility study to build an Alzheimer’s Research Center on the UC Irvine Campus and prepare for a capital campaign with a $10M seed gift to build a dedicated and named building for research and clinical services on the UC Irvine Campus.

Through the UCI MIND Leadership Council, under the direction of the faculty co-directors and volunteer chair, we hope to achieve these major goals to complement our current programs, develop new ones, and further strategic funding opportunities as they become apparent.


CEO Statement

Research Today. Hope Tomorrow.

The impact of Alzheimer’s in the United States today is staggering and its impact will grow as 10,000 Baby Boomers turn 65 each day. With age as the highest risk factor, over the next 20 years the incidence of Alzheimer’s is expected to double. Few illnesses disrupt the quality of life as much as dementia.

Costs associated with caring for Alzheimer’s patients are estimated to be $1.1 trillion dollars. Our nation has adopted the first National Plan to Address Alzheimer’s Disease, NAPA, which sets forth a goal of effectively preventing and treating Alzheimer’s disease by 2025. We are in a countdown to 2025. Only 8 years away.

The Vision of UCI MIND

It is our vision to defeat Alzheimer’s disease in the next decade. To achieve this vision, UCI MIND plans to expand its world-class research and clinical care institute, focused on treating patients suffering from neurological disorders such as Alzheimer’s, Parkinson’s or Huntington’s disease. We seek to quickly move scientific discoveries into the clinic for the benefit of our patients and the community. This vision requires integration of the clinical and research programs, so that the future treatments of tomorrow can be evaluated today.

As UCI MIND advances research on Alzheimer’s disease and the related disorders, it is our goal to understand and discover the causes and conditions that affect progression and to find ways to effectively prevent and treat them as we:

Identify lifestyle factors that promote wellness and successful aging

Conduct cutting-edge research into the basic mechanisms of disease

Apply science-based discoveries in a clinical setting to benefit the community and the field

Train and educate the next generation of scientists and clinicians, and to provide education support for families and caregivers.

UCI MIND Co-Directors, Frank M. LaFerla, Ph.D. and Joshua D. Grill, Ph.D

Board Chair Statement

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Other Ways to Donate/Volunteer

Thank you for your interest in supporting research for Alzheimer’s disease and other neurological disorders at UCI MIND. Donations by check can be mailed to:UCI MIND 2646 Biological Sciences III Irvine CA 92697-4545 Or donations may be submitted securely online by going to:  https://www.mind.uci.edu/donate/ and selecting the research area you would like to support.Alzheimer’sDisease Excellence Fund: supports the advancement of biomedicalresearch at UCI MIND, such as induced pluripotent stem cell studies andthe identification of biological markers for Alzheimer’s diseaseAlzheimer’sDisease Clinic Fund: supports the advancement of clinical research at UCIMIND, such as trials of promising new treatmentsDown SyndromeProgram: supports the longitudinal research project ledby Dr. Ira Lott that examines aging and Alzheimer’s disease in individuals with Down syndromeHuntington’sDisease Program: supports HD-CARE, a partner organization that aims to advance Huntington’s disease research and clinical care at UCIThe90+ Study: supports the longitudinal research project that examines successful aging and dementia in individuals 90 years and olderYou may designate your gift in honor or in memory of someone.  The person honored or the family of the person memorialized will be sent an acknowledgement of your gift. Your gift of any size will assist researchers seeking answers. Research today translates to hope for tomorrow. For more information about philanthropic activities, to support research by volunteering to become a research participant or for other questions, contact: Linda Scheck, (949) 824-3251 or [email protected]

Geographic Area Served

Central Orange County
West Orange County
North Orange County
South Orange County
UCI MIND is Orange County's only federal- and state-funded Alzheimer's disease research center.  We serve the entire county and our research is linked with other such centers throughout the nation.

Organization Categories

  1. Medical Research - Brain Disorders Research
  2. Diseases Disorders & Medical Disciplines - Brain Disorders
  3. Medical Research - Digestive Diseases & Disorders Research

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Programs


UCI MIND Alzheimer's Disease Research Center

The UCI MIND Alzheimer’s Disease Research Center integrates clinical and basic science investigators from a variety of disciplines into a comprehensive research team that is organized into five components:

1. Education and Informational Outreach Core

2. Data, Statistical Management and Administrative Core

3. Neuropathology Brain Tissue Core.

4. Clinical research including clinical trials involving individual research participants at the UCI MIND Memory Assessment and Research Center

5. Induced Pluripotent Stem Cell (iPS) Research Stem Cell Bank Core

Alzheimer’s disease and the other dementias are complex multisystem disorders that impact the person at multiple levels (e.g., cognitive, physical, psychological, social) and, therefore, require an interdisciplinary approach to both research and care.

Budget  $1,609,239.00
Category  Medical Research, General/Other Alzheimer Disease Research
Population Served Adults At-Risk Populations Families
Program Short-Term Success  One of UCI MIND's short term successes is the work on Diet and Exercise and Physical and Cognitive Stimulation. The benefits of physical and cognitive stimulation for brain health are now well-documented in mice and are about to be tested nationwide in a clinical trial based on the work at UCI MIND. 

UCI MIND researchers have been at the forefront of demonstrating that exercise promotes brain health, improves brain function and can reverse memory deficits in mice with Alzheimer’s disease. It turns out that physical exercise increases the production of a key brain nutrient called brain-derived neurotrophic factor, (BDNF) which becomes reduced in the brains of people with Alzheimer’s disease. As individuals age, the connections between neurons, or synapses, are lost. This nationwide clinical trial will prove physical and cognitive stimulation increases critical connections, enhancing brain function in humans.

Program Long-Term Success 

Our vision is to defeat Alzheimer’s disease in the next decade. UCI MIND plans to continue expanding as a leading world-class research and clinical care institute, focused on treating patients suffering from neurological disorders. We will quickly move scientific discoveries made in the lab into the clinic to benefit our patients and the community. To do this we integrate the clinical and research programs, so that the future treatments of tomorrow can be evaluated today.

We seek to understand the causes and conditions that affect the progression of the disease and to find ways to effectively prevent and treat them as we:

Identify lifestyle factors that promote wellness and successful aging
Conduct cutting-edge research into the basic mechanisms of disease
Apply science-based discoveries in a clinical setting to benefit the community and the field
Train and educate the next generation of scientists and clinicians, and to provide education support for families and caregivers.
Program Success Monitored By  At UCI MIND, the basic scientific, molecular and cell-based research at the bench and the clinical research at the UCI MIND Memory Assessment and Research Center are closely evaluated by peer-reviewed measurements that are standard across the nation. Researchers from the other 27 Alzheimer's Disease Research Centers assess the work of individual researchers at this institute at regularly scheduled onsite visits.  In addition to reading their publications, the evaluating teams measure the success by interviews, questions and dialogue.  In this system, researchers from other major centers review the work of others in the same field.  The system is transparent and results in valid and measurable evaluations. 
Examples of Program Success  --

Management


CEO/Executive Director Dr. Joshua D. Grill Ph.D.
CEO Term Start July 2015
CEO Email [email protected]
CEO Experience
Joshua D. Grill, Ph.D. Co-Director, UCI MIND
Dr. Grill is an Associate Professor of Psychiatry and Human Behavior at UC Irvine. He is the Co-Director of the Institute for Memory Impairments and Neurological Disorders (UCI MIND) and the Associate Director of the UCI Alzheimer’s Disease Research Center (ADRC).

He also directs the Outreach, Recruitment, and Education Core for the UCI ADRC and is the leader of the Recruitment and Retention Unit for the UCI Institute for Clinical and Translational Science (ICTS).

Dr. Grill earned his doctorate in Neuroscience in the Department of Neurobiology and Anatomy at the Wake Forest University School of Medicine. His research is focused on clinical trials across the spectrum of Alzheimer’s disease and he has published a number of important findings on trial design, recruitment and retention, and research ethics.

Dr. Grill also recently launched a new online recruitment tool called the UCI Consent-2-Contact (C2C) Registry to match adults interested in research participation with clinical studies at UCI. The Registry aims to improve the rate at which people are enrolled in clinical research, helping UCI investigators move more quickly toward treatments and cures for our nation’s most pressing health problems, such as Alzheimer’s disease and cancer.

Former CEOs and Terms

Name Start End
Frank LaFerla Ph.D. July 2009 June 2014
Dr. Carl Cotman Ph.D. Jan 1985 June 2009

Senior Staff

Name Title Experience/Biography
Ms. Chelsea Cox MPH, MSW Associate Director of Education --
Mr. Dan Hoang Data Manager --
Ms. Luter Liu Chief Financial Officer --
Ms. Linda Scheck Director of Development and Donor Stewardship --
Ms. Andrea Wasserman Adminstrator --

Awards

Award Awarding Organization Year
-- -- --

Affiliations

Affiliation Year
-- --

External Assessments and Accreditations

External Assessment or Accreditation Year
-- --

Collaborations

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Staff Information

Number of Full Time Staff 35
Number of Part Time Staff 6
Number of Volunteers 20
Number of Contract Staff 0
Staff Retention Rate % --
Staff Professional Development Yes

Staff Demographics

Ethnicity African American/Black: --
Asian American/Pacific Islander: --
Caucasian: --
Hispanic/Latino: --
Native American/American Indian: --
Other: --
Other (if specified): --
Gender Female: --
Male: --
Not Specified --

Plans & Policies

Organization has Fundraising Plan? --
Organization has Strategic Plan? --
Years Strategic Plan Considers --
Management Succession Plan --
Organization Policies And Procedures --
Business Continuity of Operations Plan --

Risk Management Provisions

Nondiscrimination Policy --
Whistle Blower Policy --
Document Destruction Policy Yes
Directors and Officers Insurance Policy --

Reporting and Evaluations

Management Reports to Board? N/A
CEO Formal Evaluation and Frequency Yes Annually
Senior Management Formal Evaluation and Frequency Yes Annually
Non Management Formal Evaluation and Frequency -- --

Government Licenses

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CEO Comments

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Foundation Comments

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Governance


Board Chair Mr. Randy Platt Co-Founder, CEO, Chairman
Board Chair Company Affiliation Care Partners At Home
Board Chair Term Sept 2015 - Jan 2018
Board Co-Chair --
Board Co-Chair Company Affiliation --
Board Co-Chair Term -

Board Members

Name Company Affiliations Status
Ms. Jeannine Bonesteele HCP, Inc. Voting
Ms. Kim Butrum Silverado Voting
Mr. Marc Carlson DocuSign, Inc. Voting
Ms. Jacqueline DuPont Ph.D. Irvine Cottages and Assured InHome Care Voting
Mr. William Edwards EGS Global Voting
Ms. Rosalyn Laudati Ph.D. Psychologist Voting
Ms. Virginia Naeve Community Volunteer, Family member Voting
Mr. Keith Swayne Founder Keith and Judy Swayne Familty Foundation Voting
Mr. Burton Young Principal and Founder Sperry Commercial Voting

Constituent Board Members

Name Company Affiliations Status
-- -- --

Youth Board Members

Name Company Affiliations Status
-- -- --

Additional Board Members and Affiliations

Name Company Affiliations Status
-- -- --

Board Demographics

Ethnicity African American/Black: 0
Asian American/Pacific Islander: 0
Caucasian: 10
Hispanic/Latino: 0
Native American/American Indian: 0
Other: --
Other (if specified): --
Gender Female: 5
Male: 5
Not Specified 0

Board Information

Board Term Lengths 2
Board Term Limits 0
Board Meeting Attendance % 50%
Written Board Selection Criteria --
Written Conflict Of Interest Policy Yes
Percentage of Monetary Contributions 100%
Percentage of In-Kind Contributions 100%
Board Orientation Yes

CEO Comments

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Foundation Comments

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Standing Committees

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Financials


Revenue vs. Expense ($000s)

Expense Breakdown 2016 (%)

Expense Breakdown 2015 (%)

Expense Breakdown 2014 (%)

Prior Three Years Total Revenue and Expense Totals

Fiscal Year 2016 2015 2014
Total Revenue $3,099,151 $3,577,823 $3,079,736
Total Expenses $3,040,173 $3,158,577 $3,137,683

Prior Three Years Revenue Sources

Revenue By Revenue Source
Fiscal Year 2016 2015 2014
Foundation and
Corporation Contributions
-- -- --
Government Contributions $1,845,652 $1,839,793 $1,016,782
    Federal $1,563,852 $1,557,993 $734,982
    State $281,800 $281,800 $281,800
    Local -- -- --
    Unspecified -- -- --
Individual Contributions $187,879 $732,508 $1,085,206
Indirect Public Support $543,469 $507,823 $464,169
Earned Revenue -- -- --
Investment Income, Net of Losses $178,576 $159,430 $148,079
Membership Dues -- -- --
Special Events -- -- --
Revenue In-Kind -- -- --
Other $343,575 $338,269 $365,500

Prior Three Years Expense Allocations

Expense By Type
Fiscal Year 2016 2015 2014
Program Expense $2,219,229 $2,167,545 $2,455,031
Administration Expense $552,900 $609,700 $452,787
Fundraising Expense $268,044 $381,332 $229,865
Payments to Affiliates -- -- --
Total Revenue/Total Expenses 1.02 1.13 0.98
Program Expense/Total Expenses 73% 69% 78%
Fundraising Expense/Contributed Revenue 10% 12% 9%

Prior Three Years Assets and Liabilities

Assets and Liabilities
Fiscal Year 2016 2015 2014
Total Assets -- -- --
Current Assets -- -- --
Long-Term Liabilities -- -- --
Current Liabilities -- -- --
Total Net Assets -- -- --

Short Term Solvency

Fiscal Year 2016 2015 2014
Current Ratio: Current Assets/Current Liabilities nan nan nan

Long Term Solvency

Fiscal Year 2016 2015 2014
Long-term Liabilities/Total Assets nan% nan% nan%
Endowment Value --
Spending Policy N/A
Percentage(If selected) --
Are you currently in a Capital Campaign? No
Capital Campaign Purpose --
Campaign Goal --
Capital Campaign Dates -
Capital Campaign Raised-to-Date Amount --
Capital Campaign Anticipated in Next 5 Years? --

CEO Comments

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Foundation Comments

This organization is a part of the University of California, Irvine. The financial data provided in the charts and graphs for the previous three years reflects this organization's operations, while the posted audits and 990s reflect the UCI Foundation's operations. Summary financial data is per the financials and consultation with the organization.

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